• A meta-analysis of 34 clinical trials concluded that acupressure reduces migraine intensity and frequency more effectively than some pharmaceutical treatments (Liu et al., 2024). View Study
• A randomized controlled study found that auricular stimulation on migraine-specific points provides significant pain relief within minutes (Allais et al., 2011). View Study
• Acupressure was shown to be more effective than muscle relaxants in treating chronic headaches, with long-term benefits lasting up to 6 months (Hsieh et al., 2010). View Study

• A review of 23 clinical trials (1,689 patients) confirmed that auricular acupressure enhances sleep quality, with effects comparable to benzodiazepine sleep aids (Li et al., 2024). View Study
• A controlled study on insomnia patients demonstrated that auricular stimulation with magnetic pellets improves sleep efficiency, as measured by polysomnography (Lo et al., 2013). View Study
• In a double-blind trial, pulsed electromagnetic therapy reduced sleep onset time and night awakenings, with 70% of participants reporting significant improvement (Pelka et al., 2001). View Study

• A meta-analysis of 27 randomized trials found that acupressure significantly reduces anxiety levels across multiple populations (Chen et al., 2022). View Study
• A clinical study on auriculotherapy confirmed that magnetic ear stimulation lowers stress markers, with effects comparable to pharmacological treatments (Munhoz et al., 2022). View Study

• Trigeminal nerve modulation → Reduces migraine-related neurogenic inflammation.
• Vagus nerve activation → Promotes relaxation and regulates pain processing.
• Melatonin and cortisol regulation → Supports sleep cycles and reduces stress-induced sleep disruption.
• Neurovascular stabilization → Addresses circulatory imbalances linked to migraine attacks and poor sleep quality.

• Liu et al. (2024) – Meta-analysis of 34 clinical trials (n=3,365 patients) : Acupressure and acupuncture outperformed pharmaceutical migraine treatments in reducing attack severity and frequency (p < 0.05).
• Allais et al. (2011) – Randomized controlled trial : Auricular stimulation targeting migraine-specific points led to a significant reduction in pain intensity within 10–120 minutes, with superior results compared to placebo (p < 0.001).
• Hsieh et al. (2010) – Acupressure vs. muscle relaxant (n=28 patients) : The acupressure group exhibited a greater reduction in pain intensity, with effects lasting up to 6 months (p = 0.047).

• Trigeminal nerve modulation, reducing neurogenic inflammation.
• Vagal nerve activation, shifting autonomic balance toward parasympathetic dominance.
• Endogenous opioid release, enhancing pain modulation.

• Li et al. (2024) – Review of 23 clinical trials (n=1,689 patients) : Acupressure significantly improved sleep quality, with effects comparable to benzodiazepines (p < 0.05).
• Lo et al. (2013) – Controlled trial on insomnia patients (n=27, elderly group) : Auricular stimulation with magnetic pellets resulted in a statistically significant improvement in sleep efficiency, confirmed via polysomnography.
• Pelka et al. (2001) – Double-blind trial on pulsed electromagnetic field therapy (n=101 patients) : 70% of participants experienced reduced sleep onset latency and fewer awakenings, with significant results compared to placebo (p < 0.001).

• Cortisol reduction, improving the body's natural sleep cycle.
• Melatonin regulation, supporting circadian rhythm alignment.
• Enhanced slow-wave activity (SWA), promoting restorative sleep.

• Chen et al. (2022) – Meta-analysis of 27 randomized trials : Acupressure interventions led to a significant reduction in anxiety levels across multiple populations (effect size: –1.15, p < 0.001).
• Munhoz et al. (2022) – Auriculotherapy on stress & anxiety in healthcare workers : Magnetic ear stimulation lowered stress markers, with results comparable to pharmacological interventions.

• Vagal nerve activation, reducing sympathetic overactivity.
• Limbic system modulation, affecting emotional regulation.

Neurovascular dysfunction in migraines and sleep disorders shares common pathways, including:

• Hypothalamic dysregulation, disrupting circadian rhythms and pain processing.
• Autonomic nervous system imbalance, leading to migraine susceptibility and sleep disturbances.
• Serotonin and dopamine pathway alterations, affecting both pain perception and sleep stability.

➡ These findings suggest that non-invasive stimulation techniques, such as auricular acupressure and biomagnetic therapy, may play a role in addressing these underlying mechanisms.

1. Liu et al., 2024 – Efficacy of Acupuncture-Related Therapy for Migraine: A Systematic Review and Network Meta-Analysis. Journal of Pain Research. Read Study
2. Allais et al., 2011 – Ear acupuncture in the treatment of migraine attacks: a randomized trial on the efficacy of appropriate versus inappropriate acupoints. Neurological Sciences. Read Study
3. Hsieh et al., 2010 – Acupressure and physical therapy in patients with chronic neck pain: a comparison study. American Journal of Chinese Medicine. Read Study
4. Li et al., 2024 – Auricular Acupuncture for Migraine: A Systematic Review Protocol. Medicine (Baltimore). Read Study
5. Lo et al., 2013 – Auricular acupressure improves the quality of life in elderly with insomnia. Complementary Therapies in Medicine. Read Study
6. Pelka et al., 2001 – Pulsed electromagnetic field therapy in the treatment of pain and other symptoms in fibromyalgia: a randomized controlled study. Journal of Psychosomatic Research. Read Study
7. Chen et al., 2022 – Auricular Acupuncture for Migraine: A Systematic Review Protocol. Medicine (Baltimore). Read Study
8. Munhoz et al., 2022 – Effect of Auricular Acupuncture with Semi-Permanent Ear Needles on Controlling Migraine Symptoms: A Single-Blind Randomized Clinical Trial. Journal of Acupuncture and Meridian Studies. Read Study